The coagulation system and its function in early immune defense
نویسندگان
چکیده
منابع مشابه
The coagulation system and its function in early immune defense.
Blood coagulation has a Janus-faced role in infectious diseases. When systemically activated, it can cause serious complications associated with high morbidity and mortality. However, coagulation is also part of the innate immune system and its local activation has been found to play an important role in the early host response to infection. Though the latter aspect has been less investigated, ...
متن کاملCoagulation, an ancestral serine protease cascade, exerts a novel function in early immune defense.
Phylogenetically conserved serine protease cascades play an important role in invertebrate and vertebrate immunity. The mammalian coagulation system can be traced back some 400 million years and shares homology with ancestral serine proteinase cascades that are involved in, for example, Toll receptor signaling in insects and release of antimicrobial peptides during hemolymph clotting. In the pr...
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THROMBOSIS AND HEMOSTASIS Coagulation, an ancestral serine protease cascade, exerts a novel function in early immune defense
1Department of Clinical Sciences, Biomedical Center, Lund University, Lund, Sweden; 2Center for Infectious Medicine, Karolinska Institutet, Department of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden; 3Department of Preclinical Research and Development, CSL Behring GmbH, Marburg, Germany; and 4Department of Molecular Biology and Functional Genomics, Stockholm University, ...
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ژورنال
عنوان ژورنال: Thrombosis and Haemostasis
سال: 2014
ISSN: 0340-6245,2567-689X
DOI: 10.1160/th14-01-0053